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Therapeutic potential of CBD for anxiety disorders – What does the research show?
Cannabidiol (CBD) – a key active ingredient in the cannabis plant – is increasingly becoming the focus of research into the treatment of mental illness. A recent review (meta-analysis) carefully examines the effectiveness of CBD in anxiety disorders such as generalised Anxiety Disorder(GAD), Social Phobia (SAD) und Panic Attacks.
Science shows that CBD can actually have positive effects on anxiety disorders. Early studies found that CBD can alleviate acute feelings of anxiety, for example during simulated public appearances. Modern clinical trials have shown significant reductions in subjectively experienced anxiety as well as changes in areas of the brain associated with emotional regulation. sciencedirect.com.
The summary of current studies paints a clear picture: CBD is particularly effective in treating SAD, GAD and panic disorders an anxiolytic effect. In some subjects, a dose of 300 mg led to a significant reduction in anxiety. Interestingly, these effects were accompanied by neurobiological changes – for example in the amygdala and hippocampus – indicating a profound neural effect.
Furthermore, CBD has a favourable risk-benefit profile: it relieves anxiety without the psychoactive side effects of THC. Its safety profile is also comparatively good – the studies reviewed mainly reported mild side effects such as fatigue or dry mouth, and serious complications were rare.
Despite the promising results, challenges remain: the doses, forms of administration (oral, sublingual, inhalation) and study designs examined vary greatly. This makes direct comparisons and a universal assessment difficult. Some studies have methodological weaknesses, such as small sample sizes, open designs or a lack of control groups. Nevertheless, the authors of the meta-analysis consider CBD to be a promising new option for the treatment of anxiety disorders, both as a standalone treatment and as a supplement to existing therapies.
Several large-scale, randomised, placebo-controlled studies are currently underway to further investigate the anxiolytic effects of CBD, with the particular aim of defining standardised dosages, mechanisms of action and long-term effects.
Conclusion: Current research suggests that CBD can be used effectively and safely to treat anxiety disorders. However, structured, evidence-based application is only possible with further high-quality studies. Anyone wishing to use CBD to support their mental health should therefore rely on tested products and seek medical advice as a matter of urgency – particularly with regard to dosage, interactions and individual tolerance.
Quelle:
Therapeutic Potential of Cannabidiol (CBD) by Anxiety Disorder– Meta-Analyse, ScienceDirect (2024)
https://www.sciencedirect.com/science/article/pii/S0165178124003342
